Abstract Bouveret’s Syndrome is the rarest form of gallstone ileus. It is characterized by the passage of a large gallstone through a cholecystoduodenal fistula resulting in obstruction of the proximal bowel. The rarity, and non-specific presentation of Bouveret’s Syndrome, make it a frequently overlooked diagnosis, with a significant associated mortality. We report the case of […]
Abstract Everybody is at risk for cancer yet environmental factors, life style and diet as well as genetic factors influence the individual cancer risk. Targeted or personalized cancer prevention is based on the knowledge of the molecular characteristics of the tumor to be prevented, the molecular mechanisms of action of the compounds to be used […]
Abstract Despite large investments in drug development, the overall success rate of drugs during clinical development remains low. One prominent explanation is flawed preclinical research, in which the use and outcome of animal models is pivotal to bridge the translational gap to the clinic. Therefore, the selection of a validated and predictive animal model is […]
