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  • Scientific Articles

    BioMicroelectromechanical systems: A novel approach for drug targeting in chronic diseases

    Abstract Despite of decades of research in conventional drug delivery systems many challenges are unconfronted in treatment of chronic diseases at a personalized medicine level. So there is a need for development of targeted and efficient drug delivery systems at such levels of treatment. Microelectromechanical systems have some unique characteristics like analyte sensitivity, electrical responsiveness, […]

  • Scientific Articles

    Drug delivery through nails: Present and future

    Abstract Treatment of fungal infections of nails such as onychomycosis, nail psoriasis involved oral therapy with antifungals, but it caused systemic side effects such as liver toxicity and bioavailability problems due to first pass metabolism and drug interactions. Therefore topical delivery through nails also known as transungual drug delivery system came into picture. But transungual […]

  • Scientific Articles

    Association of bone morphogenic protein 4 gene polymorphism and left ventricle hypertrophy in diabetic chronic kidney disease patients

    Abstract: Background The Bone Morphogenetic Protein 4 (BMP4) is identified to play a significant role in cardiac remodelling; gene polymorphism and its resulting associations with Left Ventricular Hypertrophy (LVH) in diabetic Chronic Kidney Disease (CKD) patients of this protein are yet to be established. Aim To analyse the association between BMP4 gene polymorphism and LVH […]

  • Scientific Articles

    Analysis of osteoporosis gene interactome to identify heterogenic genes and pathways

    Abstract Latest advances in genetics have prompted swift progress towards the efficient identification of genes tangled in complex diseases. Still, the comprehensive understanding of the relation between the physiological and molecular mechanism of genes and how they affect disease phenotypes remains a challenge for researchers and clinicians. Here, we wish to identify the osteoporosis disease […]

  • Scientific Articles

    Metabolomics for the masses: The future of metabolomics in a personalized world

    Abstract Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules. This lack of extended information may prevent clinicians from making the best possible therapeutic interventions in […]

  • Scientific Articles

    Nicotine mediated activation of Pak1/NFkB cascade in pancreatic cancer cells – A pilot study

    Abstract: Background Tobacco smoking is a major established risk factor for pancreatic cancer (PC), increasing the incidence up to six fold depending on the duration and intensity of smoking. Nicotine is a key toxin in tobacco and cigarette, which may contribute to development of pancreatitis and PC. Our previous studies revealed an aberrant expression of […]

  • Scientific Articles

    Intraosseous lipoma of the calcaneus: The non-stereotypic lesion of the bone

    Abstract Background Intraosseous lipoma is one of the rarest benign bone tumour. They have been identified in the tibia, fíbula, metatarsals, and calcaneal. They are easily misdiagnosed as the clinical presentation is nonspecific and can mimic other ligamentous or soft tissue injury. Case presentation We described a 40-year-old patient with a chronic dull pain at […]

  • Scientific Articles

    Chiropractic pain control in myelofibrosis: A case report

    Abstract: Background Myelofibrosis (MF) is a rare hematological disease. Currently available therapies mainly offer symptom control with limited curative benefits. Case presentation A 58-year-old man old man presented with MF for several years and had undergone splenectomy and targeted therapy with ruxolitinib. During the last 3 years of his life, he suffered from intractable bone […]

  • Scientific Articles

    Splenic pseudo-aneurysm complicating acute pancreatitis: Endovascular trans-catheter embolisation with coils and N-butyl cyanoacrylate

    Abstract: Splenic aneurysms are rare but life-threatening complications of acute pancreatitis. The main risk is aneurysmal rupture and subsequent death from haemorrhage if not treated promptly. For a long time, surgery has been the mainstay of definite treatment of splenic aneurysms. In this report, we highlight a partially ruptured splenic aneurysm which was successfully treated […]

  • Scientific Articles

    The Alvarado score in acute appendicitis: A 3-year audit to evaluate the usefulness in predicting negative appendicectomies in ≤16 s at QHBFT

    Abstract: Objective To evaluate the diagnostic accuracy of the Alvarado score in reducing the rate of negative appendicectomy at Queen’s Hospital, a small district general hospital in England. Methodology The retrospective, analytical study included all children who were ≤16 years old with a preliminary diagnosis of acute appendicitis undergoing appendicectomy subsequently. Children with other causes […]

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