Small molecule PAI-1 functional inhibitor : Implications for the therapy of vascular disease
Abstract Focal points Bedside Targeted pharmacologic disruption of PAI-1 function with small molecule inhibitors may have general applicability for the treatment of fibroproliferative disorders, in general, and vascular disease, in particular. The development orally compatible drugs would likely simplify delivery and patient compliance. Benchside It is apparent that PAI-1 is a multi-functional SERPIN, affecting such […]
